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1,3,5(10)-Estratrien-3-ol-17-one
English Synonyms: (8R,13S)-3-Hydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-cyclopenta[a]phenanthren-17-one;1,3,5(10)-Oestratrien-3-ol-17-one;1,3,5-Oestratrien-3-ol-17-one;3-Hydroxy-1,3,5-(10)-oestratrien-17-one;3-Hydroxy-1,3,5(10)-oestratrien-17-one;3-hydroxy-17-keto-estra-1,3,5-triene;3-Hydroxy-17-ketoestra-1,3,5-triene;3-hydroxy-17-keto-oestra-1,3,5-triene
CAS NO.: 53-16-7
USP
Assay: 98%
CAS:53-16-7
EINECS:200-164-5
Melting point: 258-260 ° C (lit.)
Specific rotation: 158 º (c = 1, dioxane)
Refractive index: 165 ° (C = 1, Dioxane)
Chemical Properties white plate crystal or crystalline powder. Stable in air. Mp256-262 ℃; Specific rotation [α] 25D +158 ° - +168 ° (dioxane), [α] 22D +152 ° (0.995%, chloroform); ethanol solution of maximum absorption at 287nm wavelength. Almost insoluble in water, soluble in dioxane, pyridine and alkali hydroxide solution, slightly soluble in ethanol (1:400), acetone, benzene, chloroform, ether and vegetable oils. Animal experiments show that there is a potential carcinogenic effects.
Use mainly for uterine hypoplasia, menstrual disorders and menopausal disorders. Ethinyl estradiol synthesis intermediates of drugs. Can cause nausea, vomiting, and dizziness. A long time can cause endometrial hyperplasia bleeding.
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