| Message: | Hydrochlorothiaxide;6-Chloro-3,4-dihydro-7-sulphamoyl-1,2,4-ben-zoth-iadi-azine 1,1-dioxcide
Molecular formula : C7H8ClN3O4S2
MW : 297.72
CAS No. :58-93-5
nature : the white crystalline powder. Melting point 273-275 ° C, soluble in acetone, alcohol-soluble and insoluble in water, chloroform, ethyl ether, soluble in sodium hydroxide solution, but it is easy to hydrolysis. Mei, slightly bitter flavor.
Preparation : Inter-chloroaniline by sulfochlorination the 5-chloro-2 ,4-chloro-p aniline, ammonia again produced by the reaction of 5-chloro-2 ,4-amino methyl aniline, the final shape of formaldehyde in a system.
purposes : the goods of thiazide diuretics which effect the typical representative of the United States in 1985 drug sales ranked one. For easy to take effect Medium and is applicable to various edema, it is the most clinically because Pai potassium adverse events, the application need to add potassium. Mice injected Shizunaga LD50 of 590mg/kg, oral LD50 for more than 8000mg/kg. |
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