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Anti-CD38 immunotoxin IB4 (IgG)-Gel |
Create: 02/27/2017 |
Expired Date: | 02/24/2021 |
Category: | Drugs&Pharmaceutical [Health&Medical&Pharmaceutical] |
Message: | This immunotoxin was achieved by conjugating/fusing the Anti-CD38 monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD38+ cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating Non Hodgkin lymphoma (NHL). |
City: | Shirley[US]
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