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Anti-CD38 immunotoxin IB4 (IgG)-RTA |
| Create: 02/27/2017 |
| Expired Date: | 02/21/2020 |
| Category: | Drugs&Pharmaceutical [Health&Medical&Pharmaceutical] |
| Message: | This immunotoxin was achieved by conjugating/fusing the Anti-CD38 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD38+ cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Non Hodgkin lymphoma (NHL). |
| City: | Shirley[US]
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| Location: |
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