| Message: | Estrogen 17alpha-Hydroxyprogesterone
Product Name: 17A-Hydroxyprogesterone
CAS: 68-96-2
EINEC: 200-699-4
MF: C21H30O3
MW: 330.4611
Assay: 99%
Grade: Pharmaceutical Grade
Appearance: White Powder
Usage: Pharmaceutical Raw Materials
Melting Point: 276 dec.
Density: 1.15g/cm3
Boiling Point: 482.9 dec.at 760 mmHg
Flash Point: 259.9 dec.
Steam Pressure: 2.37E-11mmHg at 25 dec.
Application: it is an important intermediate for the synthesis of steroid hormone and steroid progesterone drug. It can be synthesized by hydrocortisone, betamethasone, cortisone acetate, progesterone caproate, chlormadinone etc.
The 17-hydroxyprogesterone (17-OHP) test is routinely ordered as part of newborn screening in the UnitedStates to detect congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. CAH is a group ofinherited disorders caused by specific gene mutations and associated with cortisol-related enzymedeficiencies. About 90% of CAH cases are caused by a mutation in the 21-hydroxylase gene (also calledP450c1 or CYP21A2) and may be detected due to the accumulation of 17-OHP in the blood.
The 17-OHP test may be used to screen for CAH in older children or adults before symptoms appear or toconfirm a CAH diagnosis in people with symptoms.
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