| Message: | Estrogenic Steroids Dydrogesterone
Product Name: Dydrogesterone
CAS: 152-62-5
EINECS: 205-806-8
MF: C21H28O2
MW: 312.45
Grade: Pharmaceutical Grade
Appearance: White Powder
Usage: Pharmaceutical Raw Materials
Dydrogesterone, is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione.Dydrogesterone (6-dehydro-retroprogesterone)is a hormonally active, non-androgenic steroid that was developed in the 1950s.
Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity,while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10-20 times lower than that of oral micronized progesterone.
Primary or essential dysmenorrhea is a very common gynaecological phenomenon experienced by women during their reproductive years. Clinical studies have shown symptom relief and a reduction in pain with dydrogesterone treatment for dysmenorrhea.
Secondary amenorrhoea is not a specific disease, but is instead a symptom. Dydrogesterone has been found to adequately induce bleeding within a sufficiently estrogen-primed endometrium. When estradiol levels are found to be low, dydrogesterone treatment is more effective when supplemented with estrogens.
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