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Anti-IGHE (Fab-RTA) immunotoxin |
| Create: 03/30/2017 |
| Expired Date: | 03/22/2019 |
| Category: | Drugs&Pharmaceutical [Health&Medical&Pharmaceutical] |
| Message: | This immunotoxin was achieved by conjugating/fusing the Anti-IGHE Fab to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells bearing the IgE isotype. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Allergy. |
| City: | Shirley[US]
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| Location: |
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