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Anti-MSLN (scFv-PE) immunotoxin |
| Create: 03/30/2017 |
| Expired Date: | 03/12/2020 |
| Category: | Drugs&Pharmaceutical [Health&Medical&Pharmaceutical] |
| Message: | This immunotoxin was achieved by conjugating/fusing the Anti-MSLN scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of ovary cancer, stomach cancer, mesotheliomas. |
| City: | Shirley[US]
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| Location: |
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