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transferrin-RTA immunotoxin

Create: 03/30/2017
Expired Date:03/24/2021
Category: Drugs&Pharmaceutical [Health&Medical&Pharmaceutical]
Message:This immunotoxin was achieved by conjugating/fusing the transferrin to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TFRC expressing cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.
City:Shirley[US] 
Location:
 
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