| Message: | Product name:Chlormadinone acetate
Alias:6-Chloro-delta(4,6)-pregnadiene-17a-ol-3,20-dionacetate;6-Chloro-delta6-dehydro-17a-acetoxyprogesterone
CAS:302-22-7
EINECS:206-118-0
MF:C23H29ClO4
MW:404.93
MP:212ºC
Assay:99%
Reference Standard: CP
Appearance: White or slightly yellow crystalline powder
Key words:CMA Chlormadinone acetate 302-22-7 contraceptive progesterone
Application:
Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor. It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. CMA acts by blocking androgen receptors in target organs and by reducing the activity of skin 5alpha-reductase. It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production. CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus.
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