| Message: | Basic Info.
Synonyms: FC 1157a; Fareston; NK 622; NSC 613680
CAS: 89778-27-8
Appearance: White or almost white powder
Molecular Formula: C26H28ClNO·C6H8O7
Molecular Weight: 598.09
Melting Point: 158-164 ºC
Boiling Point: 535.1 ºC at 760 mmHg
Density: 1.045g/cm3
Refractive index: 1,416-1,418
Descriptions:
Fareston will display both estrogen antagonist / agonist properties in the body. This puts Fareston in the same category as Nolvadex and Clomid, the two most popular drugs in Farestons category. FARESTON is an estrogen agonist/antagonist indicated for the treatment of metastatic breast cancer in postmenopausal women with estrogen-receptor positive or unknown tumors.
Toremifene administration for a period of 3 months in men with idiopathic oligozoospermia is associated with significant improvements of sperm count, motility, and morphology, mediated by increased gonadotropin secretion and possibly a direct beneficial effect of toremifene on the testes. The above findings are also indicative of a better testicular exocrine (improved sperm parameters) response to treatment in men whose partners achieved pregnancy compared with those who did not. Further randomized, placebo-controlled trials should be conducted to determine whether this particular selective estrogen receptor modulator can be useful as an initial approach in men with oligozoospermia.
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