| Message: | 1 . Description
Alias: GRF 1-29 NH2, Sermorelin Acetate Hydrate
CAS: 86168-78-7
Sequence: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
MF: C149H246N44O42S
MW: 3357.96
Purity: 99%
Specification: 2mg/vial
Appearance: White Lyophilized Powder
Place of Origin: China
Standard: USP
Certification: SGS
Method of Analysis: HPLC
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.
2 . Details
Sermorelin acetate is a recently synthesized (man-made) peptide analogue of growth hormone releasing hormone (GHRH) a naturally occurring hormone that is produced in the hypothalamus and stimulates and controls the production of growth hormone (GH) within the pituitary gland. GHRH, which is necessary for growth and development, was first described by Nobel Laureates R. Guilleman and A Shalley. In the 1970s one of their students, William Wehrenberg, began studying which part of the GHRH molecule was essential in stimulating the pituitary gland.
By removing individual amino acids from the GHRH molecule, Wehrenberg found that only the first 29 amino acids were essential for the stimulation of GH production in the pituitary gland. Semorelin is therefore only comprised of these 29 essential amino acids, forming a short polypeptide chain that is considered one of the shortest functional fragments of the GHRH molecule. It was first developed with a one-step chromatographic method capable of separating all isomers of polyethylene glycol (PEG) from naturally occurring GHRH.
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