| Message: | Tadalafil (Cialis)
CAS NO.: 171596-29-5
Assay: 98%
Molecular Formula:C22H19N3O4
Molecular Weight:389.341
Molecular Structure:
Description: White Crystalline Powder
Storage: Shading, Confined Preservation
Action principle: tadalafil is cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) selective, reversible inhibitor, when stimulation caused local release of nitric oxide, PDE5 received tadalafil suppression, to improve the level of * * in the cavernous body of cGMP, which leads to smooth muscle relaxation, blood flows into the police organization, such as sexual stimulation produces an erection. And he Dalafeibu work. Preclinical data indicate that tadalafil no particular harm to human body.
Absorption: after oral administration of tadalafil in rapid absorption, 2 hours to reach the average maximum observed plasma concentration time after taking place in (Cmax). The effect of absorption rate and extent of food was not the tadalafil, so this right with or not with food and clothing. Medication time (morning or night) had no effect on the rate and extent of absorption.
Distribution: the average volume of distribution of about 63 liters, that tadalafil distribution into tissues. In the treatment, plasma concentration within 94% of tadalafil and protein binding. Protein binding is not affected by the impairment of renal function.
Clear: in healthy subjects with oral tadalafil average removal rate of 2..5L/hr, the average half-life of 17.5 hours. Tadalafil mainly metabolites excreted free activity, mainly from the feces (about 61% of the dose), little part is excreted in the urine (about 36% of the dose).
Appropriate to the crowd: the treatment of male erectile dysfunction. The need for incentives to make this product effective. Tadalafil not for women.
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