| Message: | Cabergoline (brand name Dostinex, cabaser, caber), a fungi derivative, is a potent dopamine receptor agonist. Numerous studies have shown that cabergoline inhibits prolactin. Currently, it is the preferred choice in medicine over the older bromocriptine because of its longer half-life and minimal side effects.
Product Description:
Cabergoline
Alias: Cabaser, Dostinex; Dostine, 6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
Cabergoline CAS: 81409-90-7
Cabergoline MF: C26H37N5O2
Cabergoline MW: 451.6
Cabergoline mp 102-104°C
Cabergoline storage temp. Store at +4°C
Cabergoline Chemical Properties White Crystalline Solid
Cabergoline Usage A dopamine D2-receptor agonist
Cabergoline Usage receptor stimulant
Usage:
1. hyperprolactinemia
2. adjunctive therapy of prolactin-producing pituitary gland tumors (prolactinomas)
3. monotherapy of Parkinson's disease in the early phase
4. combination therapy, together with levodopa and a decarboxylase inhibitor such as carbidopa, in progressive-phase Parkinson's disease
5. ablactation and dysfunctions associated with hyperprolactinemia (amenorrhea, oligomenorrhea, anovulation,
nonpuerperal mastitis and galactorrhea)
6. treatment of uterine fibroids
7. adjunctive therapy of acromegaly, cabergoline has low efficacy in suppressing levels and is highly efficient in
suppressing hyperprolactinemia that is present in 20-30% of acromegaly cases
8.and prolactin are similar structurally and have similar effects in many target tissues, therefore targeting
prolactin may help symptoms when hormone secretion can not be sufficiently controlled by other methods
9. Cushing's disease - cabergoline may be used to lower ACTH levels and cause regression of ACTH producing pituitary adenomas |
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