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PCSK9(D374T)-LDLR TR-FRET Assay Kit

Create: 03/08/2018
Expired Date:never
Category: Diagnostic equipment [Health&Medical&Pharmaceutical]
Message:PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to the ectodomain of hepatic low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. PCSK9 acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. The D374T mutation results in higher affinity of PCSK9 for LDLR. https://www.creativebiomart.net/pcsk9d374t-ldlr-tr-fret-assay-kit-465691.htm
City:[US] 
Location:
 
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