my account  log out
 

PCSK9(D374T)-LDLR TR-FRET Assay Kit

Create: 03/08/2018
Expired Date:never
Category: Diagnostic equipment [Health&Medical&Pharmaceutical]
Message:PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to the ectodomain of hepatic low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. PCSK9 acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. The D374T mutation results in higher affinity of PCSK9 for LDLR. https://www.creativebiomart.net/pcsk9d374t-ldlr-tr-fret-assay-kit-465691.htm
City:[US] 
Location:
 
Aug 25 2019Recombinant Human FGF2, None tagged433
Aug 25 2019Recombinant Human PVRL2, None tagged448
Aug 25 2019Recombinant Human PF4, None tagged459
Aug 25 2019Recombinant Human CXADR, Fc-His tagged483
Aug 25 2019Recombinant Mouse Cxadr, Fc-His tagged484
Aug 25 2019Recombinant Human CX3CL1, His tagged479
Aug 25 2019Recombinant Human CST5, His tagged436
Aug 25 2019Recombinant Human CPE, Fc tagged441
Aug 25 2019Recombinant Human Met, Fc-His tagged458
Aug 25 2019Recombinant Human CEACAM1, His tagged453

return back

Copyright © toextrade Inc. All rights reserved. Contact us