| Message: | Ipamorelin is a peptidic, selective agonist of the ghrelin/GH secretagogue receptor (GHS) and a GH secretagogue.It is a pentapeptide with the amino acid sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 that was derived from GHRP-1.
Ipamorelin or NNC 26-0161, a polypeptide hormone, is a GH secretagogue and ghrelin mimetic and analog. Ipamorelin belongs to the most recent generation of GHRPs and causes significant release of GH by itself, due both to its suppression of somatostatin (an antagonist to GHRH) and stimulation of release of GH from the anterior pituitary, similar to GHRP-2 and GHRP-6 which are compounds from the same class (GH releasing peptides). The cells that produce and release GH are known as somatotropes. Ipamorelin acts synergistically when applied during a native GHRH (growth-hormone releasing hormone) pulse or when co-administered with GHRH or a GHRH analog such as Sermorelin or GRF 1-29 (growth releasing factor, aminos 1-29). |
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