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ProName: (+/-)-Verapamil hydrochloride Manufacture
CasNo: 152-11-4
Molecular Formula: C27H38N2O4.HCl
Appearance: detailed see specifications
Application: It is an important raw material and intermediate used in Organic Synthesis,Pharmaceuticals.Agrochemicalsa and Dyestuff
DeliveryTime: prompt
PackAge: according to the clients requirement
ProductionCapacity: 1-100 Metric Ton/Month
Purity: 98%
Storage: Store in dry, dark and ventilated place
medical uses:
verapamil is used for controlling ventricular rate in supraventricular tachycardia and migraine headache
prevention.it is a class-iv antiarrhythmic and more effective than digoxin in controlling ventricular rate.verapamil is not listed as a first line agent by the guidelines provided by jama in jnc-8.however, it may be used to treat hypertension if patient has co-morbid atrial fibrillation or other types of arrhythmia.
verapamil is also used intra-arterially to treat cerebral vasospasm.verapamil is used to treat the condition cluster headache.
mechanism of action:
essential hypertension
verapamil exerts antihypertensive effects by decreasing systemic vascular resistance, usually without orthostatic decreases in blood pressure or reflex tachycardia; bradycardia (rate less than 50 beats/min) is uncommon (1.4%). during isometric or dynamic exercise verapamil does not alter systolic cardiac function in patients with normal ventricular function.
verapamil does not alter total serum calcium levels. however, one report suggested that calcium levels above the normal range may alter the therapeutic effect of verapamil.
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