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ProName: 5-Fluoroorotic acid, monohydrate
CasNo: 703-95-7
Molecular Formula: C5H3FN2O4
Appearance: white crystalline powder
Application: for synthesis use
DeliveryTime: prompt
PackAge: as per buyers
Port: shanghai
ProductionCapacity: 10 Metric Ton/Month
Purity: 99%
Storage: Room temperature
Transportation: by air/sea
LimitNum: 1 Kilogram
Heavy metal: N/A
Uses：
5-foa has become a valuable tool for research in the field of molecular genetics. it has been employed in the selection of resistant strains of saccharomyces cerevisiae that possess a mutant ura3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-foa is coverted to 5-fluorouridine monophosphate (5-fump) in yeast cells, which can become incorporated into rna or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-fdump). 5-fdump is a potent inhibitor of thymidylate synthase (ts), causing the cessation of dna synthesis. more recently, 5-foa has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of plasmodium falciparum. studies indicate that ts is the primary target of 5-foa in malarial parasites. the combination of 5-foa and uracil has been effective in treating mice infected with plasmodium yoelli. 5-foa may also have potential in the treatment of human malarial infections when used in combination with other agents.
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