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ProName: AZD9291
CasNo: 1421373-65-0
Molecular Formula: C28H33N7O2
Appearance: White powder
Application: Ramelteon is a sleep agent that selectively binds to the MT1and MT2 receptors in the suprachchiasmatic nucleus instead of binding to GABAA receptors,such as with drugs like zolpidem
DeliveryTime: Immediately
PackAge: Fluoride bottle or as required
Port: Shanghai, Hongkong, Shenzhen
ProductionCapacity: 30 Metric Ton/Day
Purity: 99%
Storage: Store in a cool and dry area, keep sealed and keep from direct light
Transportation: As required.
Details
molecular formula: c28h33n7o2
molecular weight: 499.607
purity: 99%
appearance: white powder
osimertinib (previously known as mereletinib or azd9291; trade name tagrisso) is a third-generation epidermal growth factor receptor (egfr) tyrosine kinase inhibitor (tki) drug developed by astrazeneca pharmaceuticals – for mutated egfr cancers.
azd 9291 function:
azd 9291 is an irreversible inhibitor of epidermal growth factor receptor (egfr) sensitizing and t790m resistance mutations (ic50s=15-17 nm) while sparing the wild-type form of the receptor (ic50 = 480 nm). it binds the related igf1r and herg receptors with significantly reduced potency (ic50s=2.9 and 16.2 μm, respectively). azd 9291 has been shown to inhibit tumor growth in a xenograft mouse model at oral doses of 5-10 mg/kg and has been tested clinically in patients with advanced egfr mutant non-small-cell lung cancer.
usage:
cell lines: human lung cancer cells with egfr-mutations or wild type egfr stable expression
preparation method:the solubility of this compound in dmso is >10 mm. general tips for obtaining a higher
concentration. please warm the tube at 37 °c for 10 minutes and/or shake it in the ultrasonic bath for a while.stock solution can be stored below -20°c for several months.
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