| Message: | Motor function of rodent models can be assessed with different behavioral tests and each of them evaluates changes in different aspects of the motor function. Here, Creative Biolabs conducts the open field test to analyze locomotor activity and anxiety-like behavior in a mouse or rat model.
Developed by Calvin S. Hall, the open filed test provides a useful method to simultaneously measure the exploratory behavior, total locomotor activity levels, and anxiety-like behavior in rodents. The test is based on the tendency of the animal to explore the novel area and avoid bright light. When animals are placed into the open field apparatus for the first time, they tend to remain near the walls, displaying a natural aversion to brightly lit areas. However, they also have the drive to explore a perceived threatening stimulus. The result of these two conflicting drives is anxiety. Increased exploratory behavior or locomotion in the center of arena indicates low anxiety, whereas preference for residing near walls and decreased locomotion/exploratory behavior indicate a high level of anxiety in animals. https://www.creative-biolabs.com/drug-discovery/therapeutics/open-field-test.htm |
my account
