| Message: | Immune checkpoints refer to proteins that act as T cell receptor (TCR) co-signaling partners which deliver either positive or negative signals to T lymphocytes. Blocking the actions of the immune checkpoint receptors can produce a potent anti-tumor response, and it has been regarded as one of the most promising approaches to activating therapeutic antitumor immunity. In view of the clinical success of inhibitory immune checkpoint blockade (CTLA-4, PD-1, and PD-L1), monoclonal antibodies against CD276 appear to be an attractive therapeutic strategy. Scientists in Creative Biolabs spare no efforts developing variety of well-characterized Magic™ “humanized” animal models, which can provide you with humanized immune checkpoint knock-in mouse models including humanized CD276 knock-in mouse and professional technical support. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-cd276-immune-checkpoint-knock-in-mice.htm
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