| Message: | Levobupivacaine (rINN) is a local anesthetic that is an aminoamide group. It is the S-enantiomer of bupivacaine. It is an amide derivative of azobicaine hydrochloride with an anesthetic properties.
Left bupivacaine reversibly binds to voltage-gated sodium channels to regulate ion flux and prevent neuronal impulses from initiating and delivering (stabilizing neuronal membranes), leading to analgesia and anesthesia. Compared with racemic bupivacaine, levobupivacaine is associated with less vasodilatation and has a longer duration of action.
Zambucaine hydrochloride is a sodium channel blocker for long-acting local anesthetics for epidural anesthesia. Bupivacaine is an isomer of bupivacaine, whose efficacy is similar to that of bupivacaine, reducing the risk of cardiotoxicity.
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