| Message: | CRISPR technology provides a precise and facile molecular mechanism for editing cells, tissue, and whole organisms, with wide-spread uses in experimental and applied systems. The system is derived from a prokaryotic adaptive immune system that provides DNA-encoded, RNA-mediated and sequence-specific protection against viruses. Through the use of a combination of crRNA and tracrRNA (the cas generated guiding components in native CRISPR) called sgRNA, Cas9 can be targeted to a specific genomic region. Once attached the enzyme can make a single-stranded ‘nick' or double-stranded ‘break' at a specified nucleotide. This region can be altered through the addition, subtraction or alteration of the sequence. https://www.creative-biolabs.com/drug-discovery/therapeutics/crispr-cas9-screening-service.htm. |
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