| Message: | Soluble cytokine receptors play pivotal roles in health and disease. Signaling of the IL-6 (cytokine interleukin-6) via its ligand, sIL-6R (soluble IL-6 receptor) is causative for the proinflammatory properties of IL-6 and appears to be an attractive therapeutic target for many immune diseases. Anyway, research data suggest the potential utility of antibodies against the IL-6R as a novel molecular approach for targeting STAT3-dependent lung T cell survival and for the treatment of patients with allergic asthma in humans. Currently, scientists in Creative Biolabs has established well-characterized Magic™ “humanized” mouse models and are proud to offer the humanized IL-6R knock-in mouse models for those who are pursuing novel treatment for immune-related disorders. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-il-6r-immune-checkpoint-knock-in-mice.htm. |
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