| Message: | Bolandiol is a synthetic anabolic steroid that increases lean body mass and bone mineral density without significantly stimulating the sexual accessory glands of adult male rats. Since bolandiol inhibits the production of gonadotropin and endogenous testosterone (T), we investigated its mechanism of action. We compared the efficacy of boranediol with T,5α-dihydrotestosterone (DHT), 19-nortestosterone (19-NT) and estradiol (E(2)) in vitro and in vivo. Compared with other androgens, Bolandiol has lower affinity for recombinant androgen receptor (AR), and recombinant human progesterone receptor (PR-A, PR-B) and estrogen receptors (ERalpha and β-) 1) has low but measurable affinity. ).
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