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Use of acridinium ester in labeling nucleic acid

Create: 10/09/2020
Expired Date:01/01/2021
Category: Chemical
Message:Acridine ester (NSP-DMAE-NHS), yellow powder, CAS number: 194357-64-7, is an important chemiluminescence reagent, its chemiluminescence quantum yield is higher than luminol, and it is labeled with acridine ester The conditions are mild, the labeling rate is high, and the separation is not affected after labeling. In addition, the chemiluminescence process of acridinium ester has a rapid reaction and low background, which can emit light in the presence of sodium hydroxide and hydrogen peroxide. During the oxidation reaction, the conjugate is decomposed and does not affect the luminescence of free acridine esters; in addition, acridine esters chemiluminescent reagents have good stability and are easy to store. In addition to its application in immunoassays, acridinium esters can also be used to label oligonucleotide fragment probes for genetic or microbial assays. Acridine ester compounds are very suitable for labeling DNA strands to produce chemiluminescent DNA probes. Modern medical research results show that many diseases such as cancer and genetic diseases are related to DNA mutations, and many infectious diseases are caused by viruses, bacteria or parasites in the environment. The analysis of virus specific sequence DNA is beneficial Control of the epidemic. The detection of DNA sequence and base mutation in its chain is of far-reaching significance in gene screening, early diagnosis and treatment of genetic diseases, and pathogenic gene determination. Desheng Technology has been developing chemiluminescence reagents for 12 years. After successful development, it has been put into the market and has been widely recognized by customers. The acridinium esters developed and produced have 6 different groups of products. In addition to the acridinium esters, chemiluminescent reagents also include luminol and isoluminol. The luminous efficiency of the acridine ester series is relatively high and belongs to direct luminescence.
City:Wuhan Hubei[CN] 
Location:
 
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