| Message: | The raw materials of heparin sodium are diversified and can be extracted from the small intestinal mucosa of pigs, cattle, sheep and cattle lungs. However, due to the emergence of mad cow disease, the application of heparin from cattle has been restricted. Studies have found that different sources of heparin sodium have different chemical structures and biological activities, and their adverse reactions are also different. The adverse reaction of heparin sodium from bovine source to thrombocytopenia is about twice that of heparin sodium from pig source. This has caused requirements and restrictions on the source of raw materials in various countries. It is safer to use heparin sodium from pig source.
At present, there are many methods for detecting the sources of different species of heparin sodium, such as PCR (polymerase chain reaction), NMR (nuclear magnetic resonance), ESI-MS (electrospray mass spectrometry), but these methods are usually expensive At the same time, the detection steps are cumbersome and complicated. Based on this, it is particularly important to find a simple and quick method to distinguish the sources of heparin sodium from different species. Desheng uses heparinase to enzymatically hydrolyze heparin sodium from different species, combined with anion exchange high-efficiency solution The composition analysis of disaccharides by SAX-HPLC has shown that the method is simple and effective and can be used as a method for detecting heparin sodium from different species.
Desheng is a professional manufacturer of blood collection tube reagents. It has more than ten years of R&D and production, experience, and perfect quality inspection and quality assurance system. The heparin sodium developed and produced is all derived from porcine intestinal mucosa and is mainly used as an additive for blood collection tubes. Heparin sodium has good anticoagulant effect, potency ≥150IU, high purity, fast delivery, welcome to consult and order! |
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