| Message: | 1. The role of pyruvate kinase isoenzyme in the diagnosis of hepatocellular carcinoma
The activity of pyruvate kinase increased in patients with acute hepatitis, but decreased in patients with acute liver necrosis. M2 pyruvate kinase is not only subject to the fine regulation of tumor signal pathway, but also restricts the regulation of tumor signal pathway. They are closely related: M2 pyruvate kinase can regulate the activity of tumor related signal pathway and transcription factor, and its localization in cells is regulated by cancer related signal pathway.
2. Transcriptional regulation is involved in tumor metabolism
HIF-1 mainly plays a role in hypoxia and regulates the body's ability to adapt to hypoxia. Its main function is to induce hypoxia genes and restore the oxygen content of the intracellular environment. However, M2 pyruvate kinase can increase the transcription level of HIF-1, and there is a positive feedback regulation between HIF-1 and M2 pyruvate kinase. In addition, M2 pyruvate kinase can also be localized in the nucleus and participate in transcriptional regulation and post-translational modification of proteins.
3. Regulating tumor signaling pathway
Abnormal signaling pathways can lead to many diseases, especially in tumors. The regulation of M2 pyruvate kinase involved in glycolysis pathway on tumor related molecules is one of the current research hotspots. |
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