| Message: | CAS 58-49-1 Angiotensin
Product Name: Angiotensin
Alias: Argpressin
CAS: 58-49-1
EINECS: 204-035-4
MF: C46H65N15O12S2
MW: 1084.23
Purity: 98.0%min
Grade: Pharmaceutical Grade
Appearance: White Powder
Single Impurity (HPLC) :1.0%max
Amino Acid Composition : ±10% of theoretical
Peptide Content (N%) : ≥80.0%
Water Content (Karl Fischer) : ≤8.0%
Acetate Content (HPIC) : ≤12.0%
MS (ESI):Consistent
Mass Balance: 95.0~105.0%
Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin also stimulates the release of aldosterone, another hormone, from the adrenal cortex. Aldosterone promotes sodium retention in the distal nephron, in the kidney, which also drives blood pressure up.
Angiotensin is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system. Angiotensin was independently isolated in Indianapolis and Argentina in the late 1930s (as 'angiotonin' and 'hypertensin', respectively) and subsequently characterised and synthesized by groups at the Cleveland Clinic and Ciba laboratories in Basel, Switzerland.
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