| Message: | Pregnenolone
CAS: 145-13-1
EINECS Number: 205-647-4
Formula: C21H32O2
MW: 316.4776
Molecular Structure:
Pharmaceutical Intermediates Progesterone Hormones Pregnenolone
Density: 1.09g / cm3
Melting point: 190-193 ºC
Boiling point: 443.3 ° C at 760 mmHg
Flash Point: 188.9 ° C
Vapor Pressure: 1.02E-09mmHg at 25 ° C
Properties:
Melting point 190-193 ° C
Specific rotation 28.5 ° (c = 1, EtOH)
Uses:Used as pharmaceutical intermediates progesterone
Assay: 99%
Appearance: White crystalline powder
2. Descriptions:
Pregnenolone (3β -hydroxypregn-5-en-20-one), also known as P5, is an endogenous steroid hormone. It is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. In addition, pregnenolone is biologically active in its own right, acting as a neurosteroid.
Like other steroids, pregnenolone consists of four interconnected cyclic hydrocarbons. It contains ketone and hydroxyl functional groups, two methyl branches, and a double bond at C5, in the B cyclic hydrocarbon ring. Like many steroid hormones, it is hydrophobic. Its esterified version, pregnenolone sulfate, is water-soluble.
Pregnenolone and its sulfate, like its sulfate and progesterone, belong to the group of neurosteroids that are found in high concentrations in certain areas of the brain, and are synthesized there. Neurosteroids affect synaptic functioning, are neuroprotective, and enhance myelinization. Pregnenolone and its sulfate ester are under investigation for their potential to improve cognitive and memory functioning. Pregnenolone is also being considered as a potential treatment for schizophrenia.
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