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JW 642 powder raw material high purity

Create: 07/31/2018
Expired Date:never
Category: Estropipate [Health&Medical&Pharmaceutical]
Message:II. JW 642 cycle 1. Names: Chemical Names: 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester Synonyms: JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate How JW 642 works? JW 642 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC = 3.7 nM). Displays >1000-fold selectivity for MAGL over fatty acid amidehydrolase (IC = 20.6 μM). Monoacylglycerol lipase (MAGL) isa serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. Toxicological Effects may be caused like below: Methyl Acetate – Toxicity Data: Oral LD50 (rat): >5,000 mg/kg; Oral LD50 (rabbit): 3,705 mg/kg; Skin LD50(rabbit): >5,000 mg/kg; Inhalation TCLO (human): 15,000 mg/m3; Methyl Acetate – Irritation Data: Skin (rabbit): 500 mg (24h) mild; Eyes (rabbit):100 mg (24h)moderate. For more details, please contact: Email: aas24@aasraw.com or SaviQ130@yahoo.com Website:https://www.aasraw.com/
City:Shenzhen Guangdong[CN] 
Location:
 
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