| Message: | II. JW 642 cycle
1. Names:
Chemical Names:
4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
Synonyms:
JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
How JW 642 works?
JW 642 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC = 3.7 nM). Displays >1000-fold selectivity for MAGL over fatty acid amidehydrolase (IC = 20.6 μM). Monoacylglycerol lipase (MAGL) isa serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. Toxicological Effects may be caused like below: Methyl Acetate – Toxicity Data: Oral LD50 (rat): >5,000 mg/kg; Oral LD50 (rabbit): 3,705 mg/kg; Skin LD50(rabbit): >5,000 mg/kg; Inhalation TCLO (human): 15,000 mg/m3; Methyl Acetate – Irritation Data: Skin (rabbit): 500 mg (24h) mild; Eyes (rabbit):100 mg (24h)moderate.
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